When Dr. Sebastian Charles, renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to Princeton Plainsboro Teaching Hospital after collapsing, he immediately determines all the symptoms are from TB. Dr. House has a different opinion and requests additional tests to help determine the cause of his illness. The case begins to get media attention and Dr. Charles sees a chance to further his cause by refusing to submit to any additional tests and take necessary medication in order to gain media exposure for the inadequacies of the medical system for the poor in Africa. As House confronts his patient on live television, his medical condition deteriorates and the team takes over to try to save his life. Meanwhile, Foreman fills in for House in the clinic with disastrous results and Cameron sees eye to eye with Dr. Charles and his cause.